The Cowboys dominated the Giants in a 40-0 shutout on Sunday Night Football. Quarterback Dak Prescott threw for 308 yards and four touchdowns, while running back Ezekiel Elliott added 112 yards and a score on the ground.
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The Packers defeated the Bears 38-20 in a classic NFC North rivalry game. Aaron Rodgers passed for 276 yards and three touchdowns, two of them to Davante Adams, who had 121 yards receiving.
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The Eagles upset the Patriots 25-20 in a rematch of Super Bowl LII. Jalen Hurts threw for 215 yards and two touchdowns, and also ran for 64 yards and a score. The Eagles defense intercepted Mac Jones twice and sacked him four times.
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The Rams beat the Seahawks 30-13 in a battle of NFC West contenders. Matthew Stafford had a stellar debut for the Rams, throwing for 321 yards and three touchdowns, one of them to Cooper Kupp, who had 108 yards receiving.
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The Dolphins edged the Chargers 36-34 in a thrilling shootout. Tua Tagovailoa threw for 314 yards and four touchdowns, three of them to Jaylen Waddle, who had 132 yards receiving.
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The Jaguars surprised the Colts 31-21 in an AFC South clash. Trevor Lawrence had an impressive NFL debut, throwing for 287 yards and three touchdowns, two of them to DJ Chark, who had 102 yards receiving.
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The Commanders defeated the Cardinals 20-16 in their first game under their new name. Ryan Fitzpatrick threw for 202 yards and a touchdown, while Antonio Gibson ran for 90 yards and a score.
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The Falcons beat the Panthers 24-10 in an NFC South matchup. Matt Ryan threw for 264 yards and two touchdowns, one of them to Calvin Ridley, who had 86 yards receiving.
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The Browns routed the Bengals 24-3 in a lopsided divisional game. Deshaun Watson, who missed most of last season due to suspension, threw for 248 yards and a touchdown, and also ran for another score.
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The Ravens crushed the Texans 25-9 in a one-sided affair. Lamar Jackson threw for 236 yards and two touchdowns, one of them to Marquise Brown, who had 101 yards receiving.
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The Buccaneers won their first game without Tom Brady, beating the Vikings 20-17 on a last-second field goal by Ryan Succop. Jameis Winston threw for 189 yards and a touchdown, while Leonard Fournette ran for 81 yards and a score.
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The 49ers demolished the Steelers 30-7 in a dominant performance. Brock Purdy threw for 220 yards and two touchdowns, both of them to Brandon Aiyuk, who had 89 yards receiving. Christian McCaffrey ran for 152 yards and a touchdown on just nine carries.
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The Saints beat the Raiders 27-24 in a close game. Drew Brees threw for 259 yards and two touchdowns, one of them to Michael Thomas, who had 95 yards receiving. Alvin Kamara ran for 74 yards and a score.
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The Broncos defeated the Jets 23-17 in a tight contest. Teddy Bridgewater threw for 234 yards and a touchdown, while Melvin Gordon ran for 70 yards and a score.
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